Biologist Job at Binding Minds Inc. (Certified Disability Owned Business Ente..., Boston, MA

T29RSmVGenAxWHZsWEs4Z1NFN0dEM3RHaUE9PQ==
  • Binding Minds Inc. (Certified Disability Owned Business Ente...
  • Boston, MA

Job Description

Job Description

We are seeking a highly skilled, passionate, and motivated scientist to join our diabetes research team. This position will play a key lab-based role in advancing iPSC stem cell engineering and contribute to the development of the next generation of islet cell therapies.

Responsibilities:

  • Enable and advance iPSC gene editing, cell line development, and evaluation of differentiated cells.
  • Perform routine iPSC cell culture, passaging, and media preparation.
  • Optimize workflows for iPSC CRISPR-based gene editing, gRNA screening, and delivery.
  • Develop and perform assays for on-/off-target analysis using PCR and NGS workflows.
  • Generate clonal gene-edited iPSC lines and characterize them via flow cytometry, ddPCR, dPCR, and qPCR.
  • Culture and execute routine directed differentiation of human iPSCs to pancreatic islets, performing assessments such as cell counts, viability, and metabolite analysis.
  • Assist scientists in evaluating and designing mitigation strategies to ensure genomic stability of iPSC lines and drug substances.
  • Collaborate cross-functionally to support the transfer of R&D assays to GMP environments.
  • Maintain accurate and detailed experimental records, synthesize results, prepare reports, and present findings in meetings.
  • Contribute to the development and refinement of SOPs.
  • Execute work plans efficiently and meet established deadlines.

Qualifications:

  • BS or MS in Stem Cell Biology, Cell Biology, Bioengineering, or a related field.
  • 3+ years of relevant industry experience for MS candidates, or 5+ years for BS candidates.
  • Extensive hands-on experience with human iPSC culture, gene editing, and molecular biology techniques.
  • Proficiency in gene editing and cell line development, including protocol optimization and flow-based sorting.
  • Hands-on experience with delivery methods for gene editing tools.
  • Strong communication and interpersonal skills, with the ability to work effectively in a collaborative team environment.
  • Excellent organizational skills and attention to detail in record keeping.
  • Experience in pancreatic islet directed differentiation is highly desirable.
  • Experience in transitioning research-grade processes to GMP-grade is highly desirable.

Job Tags

Similar Jobs

Heartwell Services, LLC

Life Skills Coach-CCS-Belen Job at Heartwell Services, LLC

Job Description Job Description Description: Job Description Participate as an integral member of the interdisciplinary team by implementing the Individualized Support Plan and providing regular feedback on the individual's progress. Advocate on behalf of the individual...

Veronique Oro Corp.

Accounting Associate Job at Veronique Oro Corp.

 ...creating innovative, beautiful pieces that bring the best of international design concepts to the U.S. jewelry market. With a commitment...  ...brand that values precision, integrity, and lasting impact. The Accounting Associate will play a key supporting role in ensuring the... 

Delivery & Distribution Solutions LLC

Independent Contractor Courier Job at Delivery & Distribution Solutions LLC

 ...Delivery & Distribution Solutions, LLC is a growing company looking for independent contract couriers for local parcel deliveries. To be considered, you must be familiar with the Louisville area and surrounding suburbs, have a clean driving record, clear background... 

Hello Kia of Valencia

Kia Service Technician Job at Hello Kia of Valencia

 ...locations and are looking to grow our team. Don't just go by what we have to say; take a second and read a recent article in the Signal Newspaper about our group. We are excited about our future and need the right people to join the next chapter. -new-community-based-... 

Domino's Franchise

Delivery Driver 1681S Jefferson Ave Job at Domino's Franchise

 ...kick out of customer service A can-do attitude Good presentation Friendly and sociable Qualifications Must have car insurance and valid driver's lisence. Additional Information All your information will be kept confidential according to...