Location: San Diego, CA
Seniority Level: Scientist (Mid-level)
Employment Type: Full-time
About OliX PharmaceuticalsOliX Pharmaceuticals is a clinical-stage biotechnology company dedicated to developing next-generation RNA interference (RNAi) therapeutics. Founded in 2010 and now publicly traded in Korea, our vision is to be recognized as a pioneer in next-generation nucleic acid medicines, combining advanced science with global partnerships.
At the heart of OliX’s innovation is our proprietary asymmetric siRNA (asiRNA) platform, which enables precise, durable gene silencing with minimized off-target effects. Building on this foundation, we have developed specialized delivery platforms:
This broad technology base allows OliX to pursue undruggable targets and expand across multiple therapeutic areas, from metabolic disease to dermatology, ophthalmology, and fibrosis.
Our clinical pipeline is advancing rapidly:
To accelerate innovation, OliX has forged strategic global partnerships. In 2025, we entered a worldwide collaboration with Eli Lilly to advance cardiometabolic RNAi programs, and a multi-year exclusive research partnership with L’Oréal to pioneer RNAi solutions for skin and hair regeneration. In addition, OliX maintains an active licensing collaboration with Hansoh Pharmaceutical in China, focused on developing GalNAc-asiRNA-based medicines for cardiovascular and metabolic diseases. Together, these alliances, supported by grant-backed programs and institutional stability, provide a strong foundation for growth and discovery.
By joining OliX, you will become part of a company where cutting-edge RNAi science, small-molecule innovation, and global collaboration intersect—all aimed at creating transformative therapies for patients worldwide.
Job SummaryOliX is seeking a Scientist I/II, Medicinal Chemistry to lead small-molecule design and synthesis in support of our expanding RNAi therapeutic pipeline. The successful candidate will focus on creating novel small molecules—including delivery enhancers, conjugation partners, and pharmacological modulators—that complement and advance OliX’s RNAi medicines.
This role offers the opportunity to apply classical medicinal chemistry expertise in a cutting-edge environment, directly contributing to discovery and clinical programs arising from partnerships with Eli Lilly, L’Oréal, and Hansoh Pharmaceutical.
Key ResponsibilitiesAt OliX, you will contribute to programs that sit at the intersection of small-molecule medicinal chemistry and RNAi therapeutics, helping to shape the next generation of RNA medicines. With active Phase I clinical programs, global partnerships with Eli Lilly, L’Oréal, and Hansoh, and strong grant and institutional support, OliX offers a secure, collaborative, and innovation-driven environment where your work will directly impact future therapies for patients worldwide.
We also provide a competitive compensation and benefits package, including:
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